Tirzepatide

Dual agonist peptide targeting the GLP-1 and GIP receptors.

Classification

Dual incretin receptor agonist peptide. Tirzepatide belongs to a class of compounds designed to mimic the activity of naturally occurring incretin hormones involved in nutrient sensing, energy balance, and metabolic regulation. By simultaneously activating both GLP-1 and GIP receptors, it engages multiple physiological pathways involved in appetite and metabolic function.

Target Receptors

• GLP-1 Receptor – Involved in appetite regulation, satiety signaling, and gastric emptying.
• GIP Receptor – Influences nutrient utilization, metabolic signaling, and energy balance.

Structure

Tirzepatide is a synthetic peptide based on the native GIP hormone with structural modifications that enhance receptor activity and prolong its half-life.

Research Focus

Studied for its potential effects on appetite regulation, metabolic health, body composition, and body weight management.