Fat Loss

Long-acting amylin analogue targeting amylin receptors.

Classification

Synthetic amylin receptor agonist peptide. Cagrilintide is designed to mimic the effects of amylin, a naturally occurring peptide hormone co-secreted with insulin. It belongs to a class of compounds focused on satiety signaling and appetite regulation through pathways distinct from incretin-based therapies.

Target Receptors

• Amylin Receptors – Associated with satiety signaling, gastric-emptying regulation, and food-intake control.

Structure

Cagrilintide is a synthetic analogue of the naturally occurring hormone amylin, engineered with structural modifications to improve stability and duration of action.

Research Focus

Studied for its potential effects on satiety enhancement, hunger reduction, appetite regulation, and metabolic health.

GLP-1 receptor agonist peptide.

Classification

Long-acting incretin mimetic peptide. Semaglutide belongs to the GLP-1 receptor agonist class, a group of compounds developed to replicate the biological activity of endogenous GLP-1 while significantly extending duration of action through molecular modification.

Target Receptors

• GLP-1 Receptor – Involved in appetite regulation, satiety signaling, gastric emptying, and metabolic control.

Structure

Semaglutide is a modified analogue of native GLP-1 containing amino acid substitutions and a fatty-acid side chain that increases albumin binding and extends activity.

Research Focus

Studied for its effects on appetite control, caloric intake reduction, weight management, and metabolic regulation.

Dual agonist peptide targeting the GLP-1 and GIP receptors.

Classification

Dual incretin receptor agonist peptide. Tirzepatide belongs to a class of compounds designed to mimic the activity of naturally occurring incretin hormones involved in nutrient sensing, energy balance, and metabolic regulation. By simultaneously activating both GLP-1 and GIP receptors, it engages multiple physiological pathways involved in appetite and metabolic function.

Target Receptors

• GLP-1 Receptor – Involved in appetite regulation, satiety signaling, and gastric emptying.
• GIP Receptor – Influences nutrient utilization, metabolic signaling, and energy balance.

Structure

Tirzepatide is a synthetic peptide based on the native GIP hormone with structural modifications that enhance receptor activity and prolong its half-life.

Research Focus

Studied for its potential effects on appetite regulation, metabolic health, body composition, and body weight management.

Triple agonist peptide targeting the GLP-1, GIP and Glucagon receptors.

Classification

Triple incretin and glucagon receptor agonist peptide. Retatrutide belongs to a novel class of metabolic peptides engineered to simultaneously activate GLP-1, GIP, and glucagon receptors. Unlike single- or dual-receptor agonists, Retatrutide is designed to engage multiple complementary pathways involved in appetite regulation, nutrient utilization, energy expenditure, and metabolic function through a single molecule.

Target Receptors

• GLP-1 Receptor – Involved in appetite regulation, satiety signaling, and gastric emptying.
• GIP Receptor – Influences nutrient utilization, metabolic signaling, and energy balance.
• Glucagon Receptor – Associated with energy expenditure, lipid metabolism, and glucose regulation.

Structure

Retatrutide is a synthetic peptide engineered to bind and activate all three receptors simultaneously. Structural modifications increase stability, enhance receptor affinity, and extend its duration of activity, allowing for prolonged engagement of metabolic signaling pathways.

Research Focus

Studied for its potential effects on appetite regulation, body weight reduction, energy expenditure, metabolic flexibility, and overall metabolic function. Its triple-receptor mechanism has made it a significant area of interest within obesity and metabolic research.